Through I&E’s experiential entrepreneurship courses, aspiring innovators from across Duke’s graduate and professional schools work on an idea at any stage—from exploration to launch. You can work on your own idea or project, or a faculty project currently underway.
These courses complement your area of study and further your ambitions—whether you want to change the world with an innovation, work toward your dream of someday owning a practice or business, or support a future industry or academic career.
Many additional courses cross-listed under other departments count towards the elective requirements of the Graduate & Professional I&E Certificate. Visit the Certificate page to learn more.
The date, time, and location for each course can be found in DukeHub.
Fall 2026
Kathleen Horvath
Judith Ledlee
Over the two-semester Design Climate course sequence, student teams use Design Thinking to create triple bottom line startups to address climate challenges posed by industry professionals or faculty. In Design Climate I (fall), student teams develop business ideas by working through the first three phases of Design Thinking: stakeholder empathizing, opportunity definition, and solution ideation. The semester culminates with a pitch on the startup idea that will be further vetted in Design Climate II (spring). Through this process, students learn directly from industry professionals and cultivate capabilities in Design Thinking, entrepreneurship, project management, sustainable product development, climate fundamentals, and business competencies. For more information, visit our website at designclimate.duke.edu. We highly encourage students to only register if you plan on taking both Design Climate I and II.
Instructor: Charles Hallford
This is an opportunity for students to work on commercialization plans for technologies developed at Duke University, in particular in the areas of therapeutics (pharmaceuticals), diagnostics, and medical devices. They will have access to the scientist or inventor of the technology and will also work with an academic and a business mentor. Teams will be interdisciplinary, and students will gather and analyze data, develop recommendations, formulate implementation plans, and provide other capacity-building support to clients. Student teams will follow a structured process to develop a strategy and plan for the venture.
Instructor: Amy Wyron Robinson
Students will learn to communicate why others should value their ideas and innovations, using both verbal and non-verbal elements. The first weeks of the seminar series will focus on common principles of storytelling and the ways in which stories have, historically, been the cornerstone of disseminating new ideas and information as far back as Homeric epic to as recently as Instagram and TikTok. Students will spend the remainder of the time in small groups to practice communication and design by creating and work shopping a variety of narrative materials (e.g. essay, podcast, video, presentation, etc.) related to their primary work or scholarship in another discipline.
Instructor: Amy Wyron Robinson
This course is designed to lead you to a eureka moment by teaching you how to explore the world around you for problems worth solving. Instead of jumping directly into problem solving and solution development—which can often be wasteful without a clear understanding of a given market and customer need—this course focuses on research, exploration, and discovery. It asks students to set aside pre-conceived notions, avoiding some of their own blind spots, in order to do the necessary work of collecting data about market and learning to assess it as objectively as possible. This course is ideal for anyone who wants to excel at finding white space for new innovation and entrepreneurial action.
Instructor: Ibrahim Mohedas
This is an opportunity for students to explore the commercialization potential of early-stage research being pursued at Duke University. Students will either work to evaluate their own research or be assigned research to evaluate that is actively being pursued at Duke. Students assigned projects will also have access to the researchers who have developed the technology. Convergent teams, consisting of different disciplines and perspectives will explore potential use-cases, engage with end-user groups and stakeholders, assess the competitive landscape, develop a timeline of key milestones, identify potential funding avenues, and develop a cohesive story and pitch deck.
Shep Moyle
This course is only open to Daytime MBA Students
This course is designed to lead you to a eureka moment by teaching you how to explore the world around you for problems worth solving. Instead of jumping directly into problem solving and solution development—which can often be wasteful without a clear understanding of a given market and customer need—this course focuses on research, exploration, and discovery. It asks students to set aside pre-conceived notions, avoiding some of their own blind spots, in order to do the necessary work of collecting data about market and learning to assess it as objectively as possible. This course is ideal for anyone who wants to excel at finding white space for new innovation and entrepreneurial action.
SPRING 2026
Judith Ledlee
Over the two-semester Design Climate sequence, student teams use design thinking to develop triple bottom line startups that address climate challenges posed by industry professionals or faculty. In Design Climate II, student teams develop their business ideas by prototyping, gathering market validation data, and developing their business model. The semester culminates in a pitch of the startup ideas to members of the entrepreneurship community. Students cultivate capabilities in design thinking, entrepreneurship, project management, sustainable product development, climate fundamentals & business competencies. Includes local field trips.
Ryan Bolick
This course is designed to equip aspiring entrepreneurs with the knowledge and skills needed to create, launch, and scale AI-driven startups. The curriculum provides a comprehensive understanding of the AI value chain, explores successful business models, and dives into the logistics of building a team and product in the AI space. Students will gain insights into differentiating their startups for sustainable competitive advantage and navigating the complex ethical, regulatory, and legal landscape of working with AI models. The class will include significant hand-on team project work where students will develop and refine AI startup ideas, applying the concepts learned throughout the course. Through practical case studies and interactive discussions, students will learn to identify market opportunities for the application of AI, develop differentiated AI-based products that address fairness, legal and ethical concerns, and build new ventures around bringing AI products to market.
Learn more about this course on the course page.
Steve McClelland
Tommy Sowers
This applied course immerses students in the rapid design and prototyping of AI-enabled technologies addressing real-world challenges in defense, security, and resilience. Teams work with government and industry partners to define mission-critical problems, build prototype systems, and iterate based on stakeholder feedback. Emphasis is placed on rapid experimentation, human-centered design, and operational value delivery in complex environments. Open to: Graduate and advanced undergraduate students. Prerequisites: Coursework or experience in AI, data science, systems engineering, or design innovation recommended.
Students will study the processes, factors, and strategic decisions involved in bringing a technology from the lab or research center to market – often described as 'technology commercialization' or 'technology translation.' We will examine how technologies are conceived and evaluated, the conditions enabling commercialization of the technology, factors to consider for a go-to-market strategy, and how markets, customers, and funding drive strategic choices in the path towards technology commercialization. Intellectual property, regulatory considerations, financing structures, factors in licensing/startup decisions, and assessing market needs and competitive landscape will also be included.
Eric Richardson
The Design in Healthcare 2 course is an experiential program and continuation of Design in Healthcare 1. It requires extensive team interaction and the direct application of skills in the process of preparing a medical device technology for development and eventual commercialization. Teams work through a development strategy to determine what work will be required to bring their technology forward, and the funding requirements and timing to raise capital at key milestones. The course concludes with an investor pitch to an outside panel of seasoned CEOs, VCs, and other members of the community. Prerequisite: Innovation & Entrepreneurship 720. Instructor consent required.
Amy Wyron Robinson
Students will learn to communicate why others should value their ideas and innovations, using both verbal and non-verbal elements. The first weeks of the seminar series will focus on common principles of storytelling and the ways in which stories have, historically, been the cornerstone of disseminating new ideas and information as far back as Homeric epic to as recently as Instagram and TikTok. Students will spend the remainder of the time in small groups to practice communication and design by creating and workshopping a variety of narrative materials (e.g. essay, podcast, video, presentation, etc.) related to their primary work or scholarship in another discipline.
Jamie Jones
Max Stern
Do you want to design a business model around either your own idea or someone else's problem? In New Ventures Develop you'll learn to assess opportunities, develop and test business models, understand your financials, and build successful teams. If you've validated an idea through New Ventures Discover or through your independent customer discovery process, New Ventures Develop can facilitate idea to action. In this course, student teams will develop core elements of a strategy for a technology or business idea; detail will be suitable for a business plan document for a company seeking initial investment; strategy will serve as a foundation for a first operating plan for company.
Learn more about this course and the application/matching process here: https://fuquacei.notion.site/
Jon Fjeld
Graduate students often have expertise in particular domains, but little business experience. Attaining business experience can take years and is often hard to navigate. Using entrepreneurship as a backdrop, this course provides a broad overview of business, including practical business fundamentals and theoretical frameworks for critical thinking. The course achieves this through theoretical frameworks, experiential education, and an analysis of competing companies. Students will experience the early stages of a typical startup, examine theoretical basis for startup success, understand managing and operating within an organization, and conduct a business analysis of competing companies.
Tso-Pang Yao
Introduction to major issues in developing a drug to treat a disease in an interdisciplinary lecture-based and team-based learning environment. Translation of principles in biomedical sciences, biomedical engineering, and chemistry along with innovative approaches to develop a hypothetical drug for treating a disease of choice. Hypothetical development of model compounds, target analysis, and in vitro and in vivo models to test drug efficacy. Course requires one of the following (or equivalent): Pharmacology and Cancer Biology 533, Chemistry 518, or Biomedical Engineering 577.
Shep Moyle
This course is only open to Daytime MBA Students
This course is designed to lead you to a eureka moment by teaching you how to explore the world around you for problems worth solving. Instead of jumping directly into problem solving and solution development—which can often be wasteful without a clear understanding of a given market and customer need—this course focuses on research, exploration, and discovery. It asks students to set aside pre-conceived notions, avoiding some of their own blind spots, in order to do the necessary work of collecting data about market and learning to assess it as objectively as possible. This course is ideal for anyone who wants to excel at finding white space for new innovation and entrepreneurial action.